| Current Research Studies |
・Short stature caused by a mutant growth hormone. N Engl J Med 334, 432-436, 1996
・Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells. J Biol Chem 272, 12897- 12900, 1997
・Biologically inactive growth hormone caused by an amino acid substitution. J Clin Invest 100, 1159-1165, 1997
・Novel compound heterozygous mutations of growth hormone (GH) receptor gene in a patient with GH insensitivity syndrome. J Clin Endocrinol Metab 82, 3705-3709, 1997
・Cloning and characterization of the 5’-flanking region of the human growth hormone secretagogue receptor gene. J Biol Chem 273, 33885-33888, 1998
・Cloning and characterization of the 5’-flanking region of the human growth hormone–releasing hormone receptor gene. J Biol Chem 274, 12108-12114, 1999
・Dual action of eicosapentaenoic acid in hepatoma cells. ＪBiol Chem 276, 31422-31428, 2001
・Novel function of the transactivation domain of a pituitary-specific transcription factor, Pit-1. J Biol Chem 277, 45141-45148, 2002
・Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J Biol Chem 277, 5667-5674, 2002
・A study of carotid intima-media thickness in GH-deficient Japanese adults during onset among adults and children. Eur J Endocrinol 148, 333 –338, 2003
・The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats. Life Sci 72, 2517-2524, 2003
・The R271W mutant form of Pit-1 does not act as a dominant inhibitor of Pit-1 action to activate the promoters of GH and prolactin genes. Eur J Endocrinol 148, 619-625, 2003
・Cloning and characterization of the 5’-flanking region of the human ghrelin gene. Biochem Biophys Res Commun 305, 186-192, 2003
・Lactogenic hormone responsive element reporter gene activation assay for human growth hormone. GH & IGF Res 13, 275-281, 2003
・Cloning of a protein binding to the most proximal Pit-1 binding element of prolactin gene from human pituitary cDNA library. Mol Cell Endocrinol 30;207, 31-8. 2003
・Diverse regulation of full-length and truncated growth hormone receptor expression in 3T3-L1 adipocytes. Mol Cell Endo- crinol 210, 21-29, 2003
・Direct causes of death in Japanese patients with hypopituitarism as analyzed from a nation-wide autopsy database. Eur J Endocrinol 150, 149-152, 2004
・A variety of phenotype with R161Q germline mutation of the von Hippel-Lindau tumor suppressor gene in Japanese kindred. Int J Mol Med 13(3), 401-404, 2004
・Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC. Life Sci 12;74(17), 2097-2109, 2004
・Intravenous adminstration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects. Eur J Endocrinol 150, 149-152, 2004
・Gene expression profile in the heart of spontaneous dwarf rat: In vivo effects of growth hormone Biochem Biophys Res Commun 341, 88-93, 2006
・A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma Int Med 45, 265-269, 2006
・The N131S mutation in the von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas. Endocr J 53, 819-827, 2006
・Health needs of patients with chronic diseases who lived through the great Hanshin earthquake. Disast Manage Resp5,8-13, 2007
・Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regul Peptid 138, 141-144, 2007
・Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency. Gastroenterol 132, 938- 943, 2007
・Hormone replacement therapy and vascular risk disorders in adult hypopituitarisma. Endocr J 54, 239-245, 2007
・McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method. Inte Med 46,1577-1583, 2007
・CXCL14 enhances insulin-dependent glucose uptake in adipo- cytes and is related to high-fat diet-induced obesity Biochem Biophys Res Commun 364, 1037-1042, 2007
・Involvement of mPOU(Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL Mol Cell Endocrinol 280, 20-29, 2008
・GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle- specific ubiquitin ligases, Atrogin-1 and MuRF1 Life Sci 82, 460-466, 2008
・Low serum IGF-I/GH ratio is associated with abnormal glucose tolerance in acromegaly Horm Res 69, 165-171, 2008
・Genetic variations at the CCAAT/Enhancer-binding protein δ are associated with metabolic phenotypes in the Japanese population Metab Synd and Relat Dis 6, 24-31, 2008
・Hepatic failure and enhanced oxidative stress in mitochondrial diabetes Endocr J 5, 509-514, 2008
・Branched-chain amino acids and arginine suppress MaFbx /atrogin -1 mRNA expression via mTOR pathway in C2C12 cell line Biochim Biophys Acta 1780, 1115-1120, 2008
・Chemerin enhances insulin signaling and potentiates insulin- stimulated glucose uptake in 3T3-L1 adipocytes FEBS Lett 582, 573-578, 2008
・Characterization of a splicing abnormality in Gitelman syndrome Am J Kid Dis 51, 1077-1078, 2008
・Identification and analysis of prophet of Pit-1-binding sites in human Pit-1 gene Endocrinol 149, 5491-5499, 2008
・Difference between Japanese and Caucasian populations in the allelic frequency of growth hormone receptor poly- morphisms. J Ped Endocrinol Metab 22, 41-46, 2009
|
